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https://doi.org/10.1016/j.jsb.2011.05.010
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Título: | A differential structure approach to membrane segmentation in electron tomography |
Fecha de publicación: | sep-2011 |
Cita bibliográfica: | Journal of Structural Biology Vol. 175, Issue 3, September 2011, Pages 372-383 |
ISSN: | 1047-8477 |
Palabras clave: | Segmentation Image Processing Electron Tomography Membrane ScaleSpace |
Resumen: | Electron tomography allows three-dimensional visualization of cellular landscapes in molecular detail. Segmentation is a paramount stage for the interpretation of the reconstructed tomograms. Although several computational approaches have been proposed, none has prevailed as a generic method and thus segmentation through manual annotation is still a common choice. In this work we introduce a segmentation method targeted at membranes, which define the natural limits of compartments within biological specimens. Our method is based on local differential structure and on a Gaussian-like membrane model. First, it isolates information through scale-space and finds potential membrane-like points at a local scale. Then, the structural information is integrated at a global scale to yield the definite segmentation. We show and validate the performance of the algorithm on a number of tomograms under different experimental conditions. |
Autor/es principal/es: | Martinez-Sanchez, Antonio Inmaculada, García Fernández, Jose-Jesús |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Ingeniería de la Información y las Comunicaciones |
URI: | http://hdl.handle.net/10201/136263 |
DOI: | https://doi.org/10.1016/j.jsb.2011.05.010 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 49 |
Derechos: | info:eu-repo/semantics/openAccess |
Descripción: | © 2011. Elsevier. This document is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Journal of Structural Biology. To access the final edited and published work see https://doi.org/10.1016/j.jsb.2011.05.010 |
Aparece en las colecciones: | Artículos: Ingeniería de la Información y las Comunicaciones |
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VersionAceptada_JSB2011.pdf | 884,48 kB | Adobe PDF | Visualizar/Abrir |
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