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https://doi.org/10.14670/HH-18-573
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Título: | MiR-101-3p targets KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº10 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Lung squamous cell carcinoma miR-1013p KPNA2 Proliferation Migration Invasion Apoptosis |
Resumen: | We herein discuss the impacts of miR-101-3p on the tumorigenesis-related cell behaviors in lung squamous cell carcinoma (LUSC) by repressing KPNA2. TCGA database was utilized to measure miR101-3p and KPNA2 levels in LUSC tissues and cells. The interaction of miR-101-3p and KPNA2-3’UTR was determined by dual luciferase assay. Western blot evaluated the protein level of KPNA2. MiR-101-3p was under-expressed in LUSC cells while KPNA2 was overexpressed. Western blot confirmed the impact of KPNA2 expression on cancer cell progression. The negative regulatory impact of miR-101-3p on KPNA2 was also verified. In vitro cell function assays revealed the suppressing effect of high miR-101-3p expression on cell invasion, migration and viability, as well as its promoting effect on apoptosis. Up-regulated miR-101-3p weakened the promoting effect of overexpressed KPNA2 on LUSC malignant progression. To conclude, miR-101-3p repressed viability, invasion, and migration, and facilitated cell apoptosis in LUSC by suppressing KPNA2. |
Autor/es principal/es: | Dong, Liangliang Jiang, Hanliang Qiu, Ting Xu, Yiming Chen, Enguo Huang, Aihua Ying, Kejing |
URI: | http://hdl.handle.net/10201/134423 |
DOI: | https://doi.org/10.14670/HH-18-573 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38,nº10 (2023) |
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27f596c1-759d-44ef-a213-befbdc46f0e5.pdf | 4,47 MB | Adobe PDF | Visualizar/Abrir |
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