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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Dong, Liangliang | - |
dc.contributor.author | Jiang, Hanliang | - |
dc.contributor.author | Qiu, Ting | - |
dc.contributor.author | Xu, Yiming | - |
dc.contributor.author | Chen, Enguo | - |
dc.contributor.author | Huang, Aihua | - |
dc.contributor.author | Ying, Kejing | - |
dc.date.accessioned | 2023-09-29T08:30:00Z | - |
dc.date.available | 2023-09-29T08:30:00Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Histology and Histopathology Vol. 38, nº10 (2023) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/134423 | - |
dc.description.abstract | We herein discuss the impacts of miR-101-3p on the tumorigenesis-related cell behaviors in lung squamous cell carcinoma (LUSC) by repressing KPNA2. TCGA database was utilized to measure miR101-3p and KPNA2 levels in LUSC tissues and cells. The interaction of miR-101-3p and KPNA2-3’UTR was determined by dual luciferase assay. Western blot evaluated the protein level of KPNA2. MiR-101-3p was under-expressed in LUSC cells while KPNA2 was overexpressed. Western blot confirmed the impact of KPNA2 expression on cancer cell progression. The negative regulatory impact of miR-101-3p on KPNA2 was also verified. In vitro cell function assays revealed the suppressing effect of high miR-101-3p expression on cell invasion, migration and viability, as well as its promoting effect on apoptosis. Up-regulated miR-101-3p weakened the promoting effect of overexpressed KPNA2 on LUSC malignant progression. To conclude, miR-101-3p repressed viability, invasion, and migration, and facilitated cell apoptosis in LUSC by suppressing KPNA2. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Lung squamous cell carcinoma | es |
dc.subject | miR-1013p | es |
dc.subject | KPNA2 | es |
dc.subject | Proliferation | es |
dc.subject | Migration | es |
dc.subject | Invasion | es |
dc.subject | Apoptosis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | MiR-101-3p targets KPNA2 to inhibit the progression of lung squamous cell carcinoma cell lines | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-573 | - |
Aparece en las colecciones: | Vol.38,nº10 (2023) |
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