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Título: | Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat. |
Fecha de publicación: | 22-may-2022 |
Cita bibliográfica: | Biomedicines 2022, 10, 1230 |
ISSN: | 2227-9059 |
Palabras clave: | Rats Angiotensin I Renin-angiotensin system Des-aspartate-angiotensin I Vascular reactivity Kidney Hypertension |
Resumen: | This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose– response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1 (AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endotheliumremoval, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation. This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure, which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential therapeutic target in cardiovascular disease. |
Autor/es principal/es: | Garcia-estañ Lopez, J. M. Wangensteen,Rosemary Gómez-Guzmán, Manuel Banegas, Inmaculada Rodríguez-Gómez, Isabel Jiménez, Rosario 2 , Inmaculada Banegas 1 , Isabel Rodríguez-Gómez 3 , Rosario Jiménez 2 , Juan Duarte 2 , Joaquín García-Estañ 4 and Félix Vargas 3,* Vargas,Félix |
URI: | http://hdl.handle.net/10201/134130 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess Atribución 4.0 Internacional |
Descripción: | © 2023 The Authors. This document is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc /4.0/ This document is the Accepted version of a Published Work that appeared in final form in Biomedicines. To access the final edited and published work see https://doi.org/10.3390/biomedicines10061230 |
Aparece en las colecciones: | Artículos: Fisiología |
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