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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Garcia-estañ Lopez, J. M. | - |
dc.contributor.author | Wangensteen,Rosemary | - |
dc.contributor.author | Gómez-Guzmán, Manuel | - |
dc.contributor.author | Banegas, Inmaculada | - |
dc.contributor.author | Rodríguez-Gómez, Isabel | - |
dc.contributor.author | Jiménez, Rosario | - |
dc.contributor.author | 2 , Inmaculada Banegas 1 , Isabel Rodríguez-Gómez 3 , Rosario Jiménez 2 , Juan Duarte 2 , Joaquín García-Estañ 4 and Félix Vargas 3,* | - |
dc.contributor.author | Vargas,Félix | - |
dc.date.accessioned | 2023-09-21T22:10:58Z | - |
dc.date.available | 2023-09-21T22:10:58Z | - |
dc.date.issued | 2022-05-22 | - |
dc.identifier.citation | Biomedicines 2022, 10, 1230 | es_ES |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | http://hdl.handle.net/10201/134130 | - |
dc.description | © 2023 The Authors. This document is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc /4.0/ This document is the Accepted version of a Published Work that appeared in final form in Biomedicines. To access the final edited and published work see https://doi.org/10.3390/biomedicines10061230 | - |
dc.description.abstract | This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose– response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1 (AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endotheliumremoval, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation. This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure, which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential therapeutic target in cardiovascular disease. | - |
dc.format | application/pdf | es_ES |
dc.format.extent | 12 | - |
dc.language | eng | es_ES |
dc.relation.isreferencedby | ED_IDENTRADA=1168 | - |
dc.rights | info:eu-repo/semantics/openAccess | * |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Rats | es_ES |
dc.subject | Angiotensin I | es_ES |
dc.subject | Renin-angiotensin system | - |
dc.subject | Des-aspartate-angiotensin I | - |
dc.subject | Vascular reactivity | - |
dc.subject | Kidney | - |
dc.subject | Hypertension | - |
dc.title | Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.archivorevisado | Duarte, Juan | - |
Aparece en las colecciones: | Artículos: Fisiología |
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