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Título: | Potential therapeutic effect of SO2 on fibrosis. |
Fecha de publicación: | 2019 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 34, nº 12 (2019) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Sulfur dioxide Fibrosis Therapy |
Resumen: | Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO2), which can be generated endogenously in mammals, has been found to have vasorelaxation activity, improve cardiac function and decrease myocardial injury. Endogenous SO 2 also mediates the process of fibrosis. Inhibition of endogenous SO 2 can aggravate small pulmonary artery remodeling and abnormal collagen accumulation. SO 2 treatment significantly improves pulmonary fibrosis and pulmonary arterial remodeling. Overexpression of the key enzymes associated with endogenous SO 2 generation, aspartate aminotransferase (AAT) 1 and AAT2, mimics the effect of SO 2 on the down-regulation of collagen synthesis, while AAT1 or AAT2 knockdown aggravates abnormal collagen accumulation in vascular smooth muscle cells (VSMCs). SO 2 also improves myocardial fibrosis induced by myocardial infarction or diabetes in rats, and inhibits myocardial fibroblast proliferation and migration by the extracellular signal- regulated protein kinase pathway. The mechanisms underlying the inhibition of fibrosis by SO 2 are related to its antioxidant effect, anti-inflammation effect, improvement in cardiac function, and cell proliferation inhibition. Therefore, SO 2 has a potential therapeutic effect on fibrosis. |
Autor/es principal/es: | Wang, Xin Bao Cui, Hong Du, Jun Bao |
URI: | http://hdl.handle.net/10201/124923 |
DOI: | https://doi.org/10.14670/HH-18-169 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.34,nº12 (2019) |
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