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DOI. 10.14670/HH-11-931
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Título: | Expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type |
Fecha de publicación: | 2018 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.33, nº3, (2018) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Extranodal NK/T cell lymphoma Nasal type TIM-3 LAG-3 Immunohistochemistry |
Resumen: | Objective. To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL. Methods. A total of 61 human paraffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL. Results. TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM3 and LAG-3 had no significant correlation with ENKTL patients’ age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients’ PFS. Conclusions. Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients. |
Autor/es principal/es: | Feng, Yuhua Zhong, Meizuo Liu, Yiping Wang, Leyuan Tang, Youhong |
URI: | http://hdl.handle.net/10201/118733 |
DOI: | DOI. 10.14670/HH-11-931 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.33, nº3 (2018) |
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Feng-33-307-315-2018.pdf | 8,79 MB | Adobe PDF | Visualizar/Abrir |
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