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DOI. 10.14670/HH-11-931
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Feng, Yuhua | - |
dc.contributor.author | Zhong, Meizuo | - |
dc.contributor.author | Liu, Yiping | - |
dc.contributor.author | Wang, Leyuan | - |
dc.contributor.author | Tang, Youhong | - |
dc.date.accessioned | 2022-04-05T10:54:09Z | - |
dc.date.available | 2022-04-05T10:54:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Histology and Histopathology, Vol.33, nº3, (2018) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/118733 | - |
dc.description.abstract | Objective. To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL. Methods. A total of 61 human paraffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL. Results. TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM3 and LAG-3 had no significant correlation with ENKTL patients’ age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients’ PFS. Conclusions. Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Extranodal NK/T cell lymphoma | es |
dc.subject | Nasal type | es |
dc.subject | TIM-3 | es |
dc.subject | LAG-3 | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI. 10.14670/HH-11-931 | - |
Aparece en las colecciones: | Vol.33, nº3 (2018) |
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Feng-33-307-315-2018.pdf | 8,79 MB | Adobe PDF | Visualizar/Abrir |
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