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DOI: 10.14670/HH-11-921
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Título: | Topically applied azaphenothiazines inhibit contact sensitivity to oxazolone in mice |
Fecha de publicación: | 2018 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.33, nº2, (2018) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Contact sensitivity Oxazolone Azaphenothiazines Protopic® Mice |
Resumen: | In this work we investigated the efficacy of two topically applied azaphenothiazine derivatives, 9- c h l o r o - 6 - a c e t y l ami n o b u t y l q u i n o b e n z o [ 3 , 2 - b][1,4]thiazine (compound 4) and 6-chloroethylureidoethyldiquino[3,2-b;2’;3’-e][1,4]thiazine (compound 5), in the amelioration of inflammatory symptoms of contact sensitivity (CS) to oxazolone in mice, in relation to the commercial ointment Protopic® (tacrolimus), the reference drug. The compounds were administered 24 h following elicitation of CS and, 24 h later, the parameters of inflammation, such as ear edema, blood composition, leukocyte level, numbers of cells in the draining lymph nodes, histological picture of the inflamed tissue, and the morphometric analysis, were analyzed. The study showed that the effectiveness of the studied azaphenothiazines applied as a 0.1% ointment was comparable to the reference drug regarding suppression of the inflammatory process, when all the investigated histological parameters are taken into account. |
Autor/es principal/es: | Artym, Jolanta Kocięba, Maja Zaczyńska, Ewa Zimecki, Michał Jeleń, Małgorzata Morak Młodawska, Beata Pluta, Krystian Kaleta Kuratewicz, Katarzyna Madej, Jan P. Kuropka, Piotr Kuryszko, Jan |
URI: | http://hdl.handle.net/10201/118407 |
DOI: | DOI: 10.14670/HH-11-921 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.33, nº2 (2018) |
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Fichero | Descripción | Tamaño | Formato | |
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Artym-33-223-236-2018.pdf | 25,72 MB | Adobe PDF | Visualizar/Abrir |
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