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DOI: 10.14670/HH-11-906
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Título: | Increased annexin A2 and decreased β-catenin in adenomyosis contribute to adenomyosis-associated dysmenorrhea |
Fecha de publicación: | 2017 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.32, nº12, (2017) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Annexin A2 β-catenin Adenomyosis Dysmenorrhea |
Resumen: | Objective. To investigate the expression of annexin A2 (ANXA2) and β-catenin in eutopic and ectopic endometrium, and their relationships with adenomyosis-associated dysmenorrhea. Methods. From December 2013 to June 2014, ectopic endometrium (n=30) and eutopic endometrium (n=30) of adenomyosis were collected as experimental group, and endometrium (n=30) of uterine myoma as control group from the department of gynecology and obstetrics, the affiliated hospital of Inner Mongolia medical university. The expression of ANXA2 and βcatenin was detected by immunohistochemical S-P method, followed by the Pearson correlations for the correlation analysis of ANXA2 and β-catenin with adenomyosis-associated dysmenorrhea. Meanwhile, the levels of preoperative serum ANXA2 of patients with adenomyosis (n=42) and uterine myoma (n=42) were also measured by enzyme-linked immunosorbent assay (ELISA). Results. Immunohistochemistry and ELISA identified a higher expression of ANXA2 in eutopic and ectopic endometrium of adenomysis tissues, whereas βcatenin protein was down-regulated. Furthermore, there was a significant positive correlation between ANXA2 expression and dysmenorrhea degree, while there was a negative linear correlation between β-catenin expression and dysmenorrhea degree in ectopic endometrium. Conclusion. These results suggested that increased ANXA2 and less expressed β-catenin were correlated to adenomyosis-associated dysmenorrhea. It may provide a new idea of diagnosis and treatment to adenomyosisassociated dysmenorrhea. |
Autor/es principal/es: | Liu, Li Xue Wu, Yin Ga Zheng, Jian |
URI: | http://hdl.handle.net/10201/118123 |
DOI: | DOI: 10.14670/HH-11-906 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.32,nº12 (2017) |
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