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DOI: 10.14670/HH-11-906
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Liu, Li Xue | - |
dc.contributor.author | Wu, Yin Ga | - |
dc.contributor.author | Zheng, Jian | - |
dc.date.accessioned | 2022-03-18T10:11:19Z | - |
dc.date.available | 2022-03-18T10:11:19Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Histology and Histopathology, Vol.32, nº12, (2017) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/118123 | - |
dc.description.abstract | Objective. To investigate the expression of annexin A2 (ANXA2) and β-catenin in eutopic and ectopic endometrium, and their relationships with adenomyosis-associated dysmenorrhea. Methods. From December 2013 to June 2014, ectopic endometrium (n=30) and eutopic endometrium (n=30) of adenomyosis were collected as experimental group, and endometrium (n=30) of uterine myoma as control group from the department of gynecology and obstetrics, the affiliated hospital of Inner Mongolia medical university. The expression of ANXA2 and βcatenin was detected by immunohistochemical S-P method, followed by the Pearson correlations for the correlation analysis of ANXA2 and β-catenin with adenomyosis-associated dysmenorrhea. Meanwhile, the levels of preoperative serum ANXA2 of patients with adenomyosis (n=42) and uterine myoma (n=42) were also measured by enzyme-linked immunosorbent assay (ELISA). Results. Immunohistochemistry and ELISA identified a higher expression of ANXA2 in eutopic and ectopic endometrium of adenomysis tissues, whereas βcatenin protein was down-regulated. Furthermore, there was a significant positive correlation between ANXA2 expression and dysmenorrhea degree, while there was a negative linear correlation between β-catenin expression and dysmenorrhea degree in ectopic endometrium. Conclusion. These results suggested that increased ANXA2 and less expressed β-catenin were correlated to adenomyosis-associated dysmenorrhea. It may provide a new idea of diagnosis and treatment to adenomyosisassociated dysmenorrhea. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Annexin A2 | es |
dc.subject | β-catenin | es |
dc.subject | Adenomyosis | es |
dc.subject | Dysmenorrhea | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Increased annexin A2 and decreased β-catenin in adenomyosis contribute to adenomyosis-associated dysmenorrhea | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-11-906 | - |
Aparece en las colecciones: | Vol.32,nº12 (2017) |
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Liu-32-1333-1340-2017.pdf | 10,64 MB | Adobe PDF | Visualizar/Abrir |
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