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dc.contributor.authorGómez González, Nuria Esther-
dc.contributor.authorCabas, Isabel-
dc.contributor.authorRodenas, María del Carmen-
dc.contributor.authorArizcun, Marta-
dc.contributor.authorMulero, Victoriano-
dc.contributor.authorGarcía Ayala, Alfonsa-
dc.contributor.otherFacultad de Biología; Departamento de Biología Celular e Histologíaes_ES
dc.date.accessioned2021-02-13T19:32:57Z-
dc.date.available2021-02-13T19:32:57Z-
dc.date.created2017-
dc.date.issued2017-
dc.identifier.citationDevelopmental and Comparative Immunology, 76, 143-149, 2017es_ES
dc.identifier.issn0145-305X-
dc.identifier.urihttp://hdl.handle.net/10201/103221-
dc.description.abstract17α-Ethynylestradiol (EE2), a synthetic estrogen used in most oral contraceptives pills and hormone replacement therapies, is found in many water bodies, where it can modulate the fish immune response. EE2 acts as an endocrine disruptor in gilthead seabream, Sparus aurata L., a marine teleost fish of great economic value in Mediterranean aquaculture, as it induces hepatic vitellogenin gene (vtg) expression. Moreover, EE2 also alters the capacity of gilthead seabream to appropriately respond to infection although it does not behave as an immunosuppressor. Nevertheless, these previous studies have mainly focused on the head kidney leukocytes and no information exists on peritoneal leukocytes, including mast cells. In the present work, juvenile gilthead seabream fish were fed a pellet diet supplemented with EE2 for 76 days and intraperitoneally injected with hemocyanin plus imject alum adjuvant at the end of EE2 treatment and 92 days later, and the peritoneal immune response was analyzed. EE2 supplementation induced vtg expression but returned to basal levels by 3 months post-treatment. Interestingly, gilthead seabream peritoneal leukocytes express the genes encoding for the nuclear estrogen receptor α and the G protein-coupled estrogen receptor 1 and the dietary intake of EE2 induced these expression. Moreover, EE2 induced an inflammatory response in the peritoneal cavity in unvaccinated fish, which was largely maintained for several months after the cessation of the treatment. However, the impact of EE2 in vaccinated fish was rather minor and transient. Taken together, the study provides fresh information about endocrine immune disruption, focusing on peritoneal leukocytes.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent18es_ES
dc.languageenges_ES
dc.publisherElsevieres_ES
dc.relationÁmbito del proyecto (Europeo, nacional o regional): Nacional; regional Agencia/entidad financiadora: Ministerio de Economía y Competitividad; Fundación Séneca (Comunidad Autónoma de la Región de Murcia) Convocatoria: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad, Convocatoria 2014, Modalidad 1: «Proyectos de I+D+I; Programa de ayudas a las Unidades y Grupos de Excelencia Científica de la Región de Murcia Nombre del proyecto: Análisis de las vías de actuación de contaminantes de origen farmacéutico en la respuesta inmunitaria celular y en la espermatogénesis en peces; Improvement of the Mediterranean aquaculture production by biotechnological tools Código: AGL2014-53167-C3-1-R; 19883 /GERM/15es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject17α-Ethynylestradioles_ES
dc.subjectPeritoneal exudatees_ES
dc.subjectlmmune responsees_ES
dc.subjectGilthead seabreames_ES
dc.subject.otherCiencias Puras y Naturaleses_ES
dc.title17α-Ethynylestradiol alters the peritoneal immune response of gilthead seabreames_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp:// dx.doi.org/10.1016/j.dd.2017.06.002-
Aparece en las colecciones:Artículos: Biología Celular e Histología

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