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10.14670/HH-11-643
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Título: | Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology, Vol. 30, nº10, (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Isocitrate dehydrogenase 1/2 (IDH1/IDH2) Mutations Methylation Metabolism Tumorigenesis |
Resumen: | In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (α-KG) to R-2-hydroxyglutarate (2- HG). 2-HG could competitively inhibit α-KG–dependent enzymes and might therefore contribute to tumorigenesis. In addition, mutation status of IDH1/IDH2 is closely related to the progress and prognosis of certain tumors. Thus IDH1/IDH2 is considered to be a promising biomarker for early diagnosis and prognosis and targeted therapy. In this study, the current research on IDH1/IDH2 mutation, especially the mechanisms and clinical characteristics related to tumor, are reviewed. |
Autor/es principal/es: | Liu, Xiang Ling, Zhi-Qiang |
URI: | http://hdl.handle.net/10201/100050 |
DOI: | 10.14670/HH-11-643 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30,nº10 (2015) |
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Liu-30-1155-1160-2015.pdf | 572,01 kB | Adobe PDF | Visualizar/Abrir |
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