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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Liu, Xiang | - |
dc.contributor.author | Ling, Zhi-Qiang | - |
dc.date.accessioned | 2020-12-17T10:35:06Z | - |
dc.date.available | 2020-12-17T10:35:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Histology and histopathology, Vol. 30, nº10, (2015) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/100050 | - |
dc.description.abstract | In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (α-KG) to R-2-hydroxyglutarate (2- HG). 2-HG could competitively inhibit α-KG–dependent enzymes and might therefore contribute to tumorigenesis. In addition, mutation status of IDH1/IDH2 is closely related to the progress and prognosis of certain tumors. Thus IDH1/IDH2 is considered to be a promising biomarker for early diagnosis and prognosis and targeted therapy. In this study, the current research on IDH1/IDH2 mutation, especially the mechanisms and clinical characteristics related to tumor, are reviewed. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Isocitrate dehydrogenase 1/2 (IDH1/IDH2) | es |
dc.subject | Mutations | es |
dc.subject | Methylation | es |
dc.subject | Metabolism | es |
dc.subject | Tumorigenesis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.14670/HH-11-643 | - |
Aparece en las colecciones: | Vol.30,nº10 (2015) |
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Liu-30-1155-1160-2015.pdf | 572,01 kB | Adobe PDF | Visualizar/Abrir |
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