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Título: | Ubiquitinated inclusions and neuronal cell death |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Neurodegenerative Apoptosis |
Resumen: | Summary. Ubiquitinated inclusions and selective neuronal cell death are considered the pathological hallmarks of Parkinson’s disease and other neurodegenerative diseases. Recent genetic, pathological and biochemical evidence suggests that dysfunction of ubiquitin-dependent protein degradation by the proteasome might be a contributing, if not initiating factor in the pathogenesis of these diseases. In neuronal cell culture models inhibition of the proteasome leads to cell death and formation of fibrillar ubiquitin and a- synuclein-positive inclusions, thus modeling some aspects of Lewy body diseases. The processes of inclusion formation and neuronal cell death share some common mechanisms, but can also be dissociated at a certain level. |
Autor/es principal/es: | Lang-Rollin, I. Rideout, H.J. Stefanis, L. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21414 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ubiquitinated inclusions and neuronal cell death.pdf | 143,95 kB | Adobe PDF | Visualizar/Abrir |
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