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http://hdl.handle.net/10201/21414
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Lang-Rollin, I. | es |
dc.contributor.author | Rideout, H.J. | es |
dc.contributor.author | Stefanis, L. | - |
dc.date.accessioned | 2011-06-08T09:02:39Z | - |
dc.date.available | 2011-06-08T09:02:39Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21414 | - |
dc.description.abstract | Summary. Ubiquitinated inclusions and selective neuronal cell death are considered the pathological hallmarks of Parkinson’s disease and other neurodegenerative diseases. Recent genetic, pathological and biochemical evidence suggests that dysfunction of ubiquitin-dependent protein degradation by the proteasome might be a contributing, if not initiating factor in the pathogenesis of these diseases. In neuronal cell culture models inhibition of the proteasome leads to cell death and formation of fibrillar ubiquitin and a- synuclein-positive inclusions, thus modeling some aspects of Lewy body diseases. The processes of inclusion formation and neuronal cell death share some common mechanisms, but can also be dissociated at a certain level. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Neurodegenerative | es |
dc.subject | Apoptosis | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Ubiquitinated inclusions and neuronal cell death | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ubiquitinated inclusions and neuronal cell death.pdf | 143,95 kB | Adobe PDF | ![]() Visualizar/Abrir |
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