Browsing by Subject "Synthesis"

Now showing 1 - 4 of 4
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    Meta-aggregation as a Methodological Approach for theSynthesis of Qualitative Evidence in Medical Education
    (Universidad de Murcia : servicio de publicaciones, 2026) Cedeño Orejuela, José André; Luque Loor, Andy Hermógenes; Melis Sosa, Ariel; Añazco Moreira, Paola Ceciliana; Sin departamento asociado
    La creciente incorporación de la investigación cualitativa en la educación médica ha generado lanecesidad de métodos que permitan integrar sus hallazgos de forma sistemática y aplicable. En estecontexto, la meta-agregación se presenta como un enfoque metodológico robusto, basado en elpragmatismo, que sintetiza evidencia cualitativa preservando el significado original de los datos yorientándolos hacia la toma de decisiones. A través de un proceso estructurado de identificación,categorización y síntesis de hallazgos, facilita la generación de conocimiento transferible yrecomendaciones prácticas para el diseño curricular, la enseñanza y la evaluación en distintoscontextos formativos. Además, contribuye a la integración de evidencia en revisiones de métodosmixtos y al fortalecimiento de la traducción del conocimiento hacia la práctica educativa. Aunque suénfasis en la agregación puede limitar el desarrollo teórico, su valor radica en su capacidad paraproducir evidencia útil y aplicable, por lo que se propone su adopción más amplia como estrategiaclave para cerrar la brecha entre investigación cualitativa y práctica en educación médica
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    One-Step synthesis of betalains using a novel betalamic acid derivatized support
    (American Chemical Society, 2014-04-01) Jiménez-Atiénzar, Mercedes; Cabanes Cos, Juana; Escribano Cebrián, Josefa; Gandía Herrero, Fernando; García Carmona, Francisco; Bioquímica y Biología Molecular "A"
    Betalains are plant pigments with high antioxidant and cancer hemopreventive properties used by the food industry as safe colorants. Betalains are restricted to species of the order Caryophyllales, and difficulty in obtaining individual molecules has limited their structural identification and application. This study was designed to develop a betalamic acid derivatized support generated from a primary amine polymer. The novel material presents color properties of a pseudobetaxanthin, and it is stable for at least 6 months. The bond formed can be displaced at mild conditions by the addition of amines in aqueous solutions over a broad pH range and at 25 °C. This releases the betalamic acid while forming the corresponding pigment. This one-step procedure significantly simplifies the process of obtaining semisynthetic betalains, and it is optimized here for the formation of betaxanthins and betacyanins derived from tyramine, dopamine, pyrrolidine, and indoline. The new method makes access to single betalains available to the entire scientific community and could stimulate research and applications in the field.
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    Stilbenes: Characterization, bioactivity, encapsulation and structural modifications. A review of their current limitations and promising approaches
    (Taylor and Francis Group, 2022-03-02) Navarro Orcajada, Silvia; Vidal Sánchez, Francisco José; Albadelejo Maricó, Lorena; Matencio Durán, Adrián; Conesa Valverde, Irene; López Nicolás, José Manuel; Vidal Sánchez, Francisco José; García Carmona, Francisco; Bioquímica y Biología Molecular A
    Stilbenes are phenolic compounds naturally synthesized as secondary metabolites by the shikimate pathway in plants. Research on them has increased in recent years due to their therapeutic potential as antioxidant, antimicrobial, anti-inflammatory, anticancer, cardioprotective and anti-obesity agents. Amongst them, resveratrol has attracted the most attention, although there are other natural and synthesized stilbenes with enhanced properties. However, stilbenes have some physicochemical and pharmacokinetic problems that need to be overcome before considering their applications. Human clinical evidence of their bioactivity is still controversial due to this fact and hence, exhaustive basis science on stilbenes is needed before applied science. This review gathers the main physicochemical and biological properties of natural stilbenes, establishes structure-activity relationships among them, emphasizing the current problems that limit their applications and presenting some promising approaches to overcome these issues: the encapsulation in different agents and the structural modification to obtain novel stilbenes with better features. The bioactivity of stilbenes should move from promising to evident.
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    Versatile control of the submolecular motion of di(acylamino)pyridine-based [2]rotaxanes
    (2015-03-18) Martínez Cuezva, Alberto; Pastor Vivero, Aurelia; Cioncoloni, Giacomo; Orenes Martínez, Raúl Angel; Alajarín, Mateo; Symes, Mark D.; Berná Cánovas, José; Química Orgánica; WestCHEM, School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    A cyclic network of chemical reactions has been conceived for exchanging the dynamic behaviour of di(acylamino)pyridine-based rotaxanes and surrogates. X-ray diffraction studies revealed the intercomponent interactions in these interlocked compounds and were consistent with those found in solution by dynamic NMR experiments. This particular binding site was incorporated into a molecular shuttle enabled for accessing two states with an outstanding positional discrimination through chemical manipulation. Furthermore, the ability of the di(acylamino)pyridine domain to associate with external binders with a complementary array of HB donor and acceptor sites was exploited for the advance of an unprecedented electrochemical switch operating through a reversible anion radical recognition process.