Browsing by Subject "Polycycles"

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    Enantiospecific synthesis of antifungal dasyscyphin E from cupressic acid
    (Elsevier, 2017-11-16) Fernandez, Antonio; Boulifa, Ettahir; Jimenez, Fermin; Mahdjour, Soumicha; Ahmed I., Mansour; Chahboun, Rachid; Alvarez-manzaneda, Enrique; Química Orgánica
    The first synthesis of the sesquiterpene quinol dasyscyphin E has been achieved starting from cupressic acid. Key steps of the synthetic sequence are the oxidative degradation of the diterpene side chain to give a methylketone, the diastereoselective a-methylation of a protected ketoaldehyde, the subsequent intramolecular aldol condensation and the further Diels-Alder cycloaddition of a dienol ester.