Browsing by Subject "Extinction"

Now showing 1 - 4 of 4
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    Dopamine D3 receptor blockade accelerates the extinction of opioid withdrawal-induced drug-seeking behaviours and alters microglia in dopaminoceptive nuclei
    (2025-05-21) Franco García, Aureliio; Gómez Murcia, Victoria; Milanés Maquilón, María Victoria; Núñez Parra, Cristina; Farmacología
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    Feminismo, infrapolítica, extinción
    (2018-10-30) Méndez Cota, Gabriela
    Este ensayo tiene como objetivo pensar la relación entre feminismo e infrapolítica situándola en la interrogación, desde escalas impensadas, de variantes específicas del feminismo contemporáneo en Latinoamérica. Para tal fin, se ponen en perspectiva histórico - filosófica algunas de las premisas e implicaciones de la “descolonización” feminista y se comparan con los planteamientos de la “extinción feminista” elaborados por la filósofa australiana Claire Colebrook. ¿Puede ser la ética feminista de la extinción, en su nota disonante respecto a la generalizada identificación de lo femenino con el mundo de la vida, sugerir preguntas y cam inos para una práctica infrafeminista en Latinoamérica? La propuesta de este breve ensayo es que, en efecto, las meditaciones de Colebrook sugieren que no habrá una verdadera “descolonización” del feminismo sin una afirmación “infrafeminista” de la extinci ón de la vida tal y como se ha imaginado en la historia de la metafísica a través de la simbolización de la diferencia sexua
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    Morphine-withdrawal aversive memories and their extinction modulate H4K5 acetylation and Brd4 activation in the rat hippocampus and basolateral amygdala
    (2023-06) Franco García, Aurelio; Gómez Murcia, Victoria; Fernández Gómez, Francisco José; González Andreu, Raúl; Hidalgo Céspedes, Juana María; Núñez Parra, María Cristina; Milanés Maquilón, María Victoria; Farmacología
    Chromatin modification is a crucial mechanism in several important phenomena in the brain, including drug addiction. Persistence of drug craving and risk of relapse could be attributed to drug-induced epigenetic mechanisms that seem to be candidates explaining long-lasting drug-induced behaviour and molecular alterations. Histone acetylation has been proposed to regulate drug-seeking behaviours and the extinction of rewarding memory of drug taking. In this work, we studied the epigenetic regulation during conditioned place aversion and after extinction of aversive memory of opiate withdrawal. Through immunofluorescence assays, we assessed some epigenetic marks (H4K5ac and p-Brd4) in crucial areas related to memory retrieval -basolateral amygdala (BLA) and hippocampus-. Additionally, to test the degree of transcriptional activation, we evaluated the immediate early genes (IEGs) response (Arc, Bdnf, Creb, Egr-1, Fos and Nfkb) and Smarcc1 (chromatin remodeler) through RT-qPCR in these nuclei. Our results showed increased p-Brd4 and H4K5ac levels during aversive memory retrieval, suggesting a more open chromatin state. However, transcriptional activation of these IEGs was not found, therefore suggesting that other secondary response may already be happening. Additionally, Smarcc1 levels were reduced due to morphine chronic administration in BLA and dentate gyrus. The activation markers returned to control levels after the retrieval of aversive memories, revealing a more repressed chromatin state. Taken together, our results show a major role of the tandem H4K5ac/p-Brd4 during the retrieval of aversive memories. These results might be useful to elucidate new molecular targets to improve and develop pharmacological treatments to address addiction and to avoid drug relapse.
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    What do we know about parasites of wildlife in high biodiversity areas with anthropogenic disturbance? The special case of Mexico
    (Cambridge University Press, 2019-01-26) Muñoz García, Claudia Irais; Berriatua Fernández de Larrea, Eduardo; Martínez-Carrasco Pleite, Carlos; Sanidad Animal; Facultad de Veterinaria
    The continual rise of anthropogenic disturbance of ecosystems has been associated with an increasing incidence of emerging diseases. The largest amount of data on emerging diseases relates to bacterial and viral pathogens, but there is a lack of parasite data, especially from wildlife. Monitoring wildlife parasitic diseases should be considered a priority, especially in high biodiversity regions with strong anthropogenic impacts, like Mexico, where the wildlife/livestock/human interface is associated with increased risk of disease transmission. Mexico belongs to the top-ten megadiverse countries and is located between two biogeographic regions. This situation makes Mexico a favourable region for the spillover of animal pathogens to human beings, causing pandemics, such as the one recently caused by influenza virus A (H1N1). The current state of knowledge of Mexican wildlife parasites is scarce and focuses mainly in Neotropical fauna. Moreover, this knowledge is heterogeneous for different parasite groups, especially concerning their pathologic effects and epidemiology. The goals of this review are to compile information on Mexican wildlife parasites and to identify knowledge gaps in order to stimulate research on pending epidemiological, public health, ecological and pathological areas, and to encourage the creation of more specialized groups from the perspective of the One-Health concept.