Browsing by Subject "Chagas disease"

Now showing 1 - 3 of 3
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    Anticipating the side effects of benznidazole: HLA-B*35 and patch test
    (Elsevier, 2024-04-14) Vázquez, Cristina; García-Vázquez, Elisa; Carrilero, Bartolomé; Muro, Manuel; Sánchez-Guerrero, Inmaculada; González López, Rosana; Franco, Fuensanta; Segovia, Manuel; Medicina
    ABSTRACT: Introduction: Treatment of Chagas disease frequently causes distress to patients due to a high incidence of adverse effects. Different preemptive tests have been researched to prevent these effects and to allow focus to be given to certain predisposed patients. Benznidazole is the most prescribed Chagas disease treatment in Spain. In this work, we analyzed the genetic markers HLA-B*35 allele group and HLA-B*35:05 allele specifically, as well as an allergy patch test, as benznidazole’s most frequent adverse effects are cutaneous. Methods: HLA-B intermediate-resolution genotyping was performed followed by a high-resolution level analysis. Cutaneous allergies were tested using strips impregnated with a mixture of benznidazole and placed on the upper back of patients before starting treatment. Results: In our sample of more than 400 patients, there was almost no relationship between any kind of side effect and either of the HLA-B alleles studied. The patch testing was quickly discarded as a preemptive test due to its low sensitivity (16.7%). Conclusion: In conclusion, we were unable to replicate and corroborate genetic markers identified by other groups and there is currently no test that can anticipate the adverse effects of benznidazole, therefore, more investigation should be carried out in this field.
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    The relationship between esophageal cancer, chagasic megaesophagus and HPV: myths, tales or reality?
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Munari, Fernanda Franco; Cruvinel Carloni, Adriana; Sammartino Mariano, Vânia; Syrjanen, Kari; Reis, Rui Manuel; Longatto Filho, Adhemar
    A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cellcycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development.
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    The urgent needl to develop new drugs and tools for the treatment of Chagas dlsea:se
    (Taylor & Francis, 2014-01-10) Murcia, Laura; Segovia, Manuel; Muñoz, María J.; Genética y Microbiología