Browsing by Subject "Cardiovascular"

Now showing 1 - 2 of 2
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    Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2014) Zhu, Mingzhu; Du, Junbao; Liu, Angie Dong; Holmberg, Lukas; Tang, Chaoshu; Jin, Hongfang
    In the middle of the 1980s, nitric oxide received extensive attention because of its significant effects in life science. Then, carbon monoxide and hydrogen sulfide were discovered to be gasotransmitters playing important roles in regulating cellular homeostasis. As a common air pollutant, sulfur dioxide (SO2) can cause great harm to the human body by producing free radicals, which causes oxidative damage to various organs. Recently, endogenous SO2 was found to be produced in the cardiovascular system and might be a bioactive molecule regulating the physiological activities including cardiovascular oxidative stress.
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    Heart matters: cardiac dysfunction and other autonomic changes in Parkinson’s disease
    (SAGE Publications, 2021-02-15) Gonçalves, Valeria C. ; Cuenca Bermejo, Lorena; Fernández Villalba, Emiliano; Martin Balbuena, Sebastian; Fernandes, Maria Jose da Silva; Scorza, Carla A.; Herrero Ezquerro, María Trinidad; Medicina; Facultades de la UMU
    It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson’s disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way to prevent the disease from its progressive nature yet and only its symptoms can be minimized. It is known that the process of neurodegeneration begins before the onset of motor signs and symptoms of the disease, when diagnosis is usually made. Therefore, recognizing manifested non-motor symptoms can make an early diagnosis possible and lead to a better understanding of the disease. Autonomic dysfunctions are important non-motor manifestations of Parkinson’s disease and affect the majority of patients. Importantly, heart failure is the third leading cause of death in people suffering from Parkinson’s disease. Several evidences have shown the correlation between Parkinson’s disease and the preexistence of cardiovascular diseases. Therefore, cardiovascular monitoring and identification of its dysfunctions can have a prodromal role for Parkinson’s disease. This review presents studies of the literature that can lead to a better understanding of Parkinson’s disease with special attention to its relation to heart and cardiovascular parameters.