Browsing by Subject "Aerobic exercise"

Now showing 1 - 6 of 6
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    Aerobic exercise remodels gut microbiota to alleviate cerebral ischemia-reperfusion injury
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Zhu, Mingjin; Zhu, Jiajie; Pan, Jiafei; Fu, Rui; Pan, Guoyuan; Zhang, Jie
    Aerobic exercise exhibits a neuroprotective role against cerebral ischemia-reperfusion (I/R) injury, and the present study explored the underlying mechanisms. Adult Sprague-Dawley rats (n=87) were used in the study, and cerebral I/R injury in rats was modeled using middle cerebral artery occlusion and reperfusion (MCAOR), followed by interval aerobic exercise training at a moderate intensity. Colonization with gut microbiota from the trained rats was performed on MCAOR rats. Neurobehavioral assessments were performed. Cerebral infarction and neuronal damage were detected by tissue staining and molecular experiments. Gut microbiota composition was analyzed by 16S rRNA gene sequencing. Neuroinflammation was detected using an enzyme-linked immunosorbent assay. Aerobic exercise ameliorated neurological deficit, spontaneous locomotor activity, and spatial learning and memory impairment in MCAOR rats (p<0.001). Further, aerobic exercise decreased infarct volume, attenuated neuronal damage, increased SYN1 and PSD95 expression, as well as reduced neuroinflammation by upregulating IL-10 and downregulating IL-6, TNF-α, IL-17, and TGF-β in MCAOR rats (p<0.05). Aerobic exercise altered gut microbiota composition in MCAOR rats. Gut microbiota colonization in rats alleviated cerebral I/R injury by reducing neurological deficit scores, promoting spontaneous locomotor activity, decreasing infarct volume, elevating SYN1 and PSD95 expression, and improving neuroinflammation (p<0.05). In conclusion, aerobic exercise remodeled the gut microbiota in rats to attenuate cognitive dysfunction and neuroinflammation after cerebral I/R.
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    Beneficios del ejercicio y/o actividad física en los cinco tipos de cáncer con mayor incidencia y mortalidad a nivel mundial: Una revisión narrativa
    (Universidad de Murcia, Servicio de Publicaciones, 2023) Fuentes-Nuñez, Javier; Olivares-Gómez, Carelia; Farías-Valenzuela, Claudio; Poblete-Aro, Carlos; Alvarez-Arangua, Sebastián; Ferrero-Hernández, Paloma
    Esta revisión tiene como objetivo declarar los beneficios del ejercicio físico y/o la actividad física en los cinco tipos de cáncer con mayor tasa mortalidad en el mundo. Se realizó una búsqueda en las bases de datos: Pubmed, Cochrane, Scopus, Web of Science, Scielo (Latinoamérica) y Medline. Los términos usados para la búsqueda fueron: “cáncer de pulmón”, “cáncer de hígado”, “cáncer de mama”, “cáncer de estómago”, “cáncer de colon”, “ejercicio físico”, “actividad física”, “ejercicio de resistencia” y “ejercicio aeróbico”. El ejercicio físico y la actividad física han demostrado beneficios tanto en variables morfológicas, metabólicas y psicológicas, teniendo un impacto positivo en el aumento de la funcionalidad, esperanza de vida y calidad de vida en pacientes con cáncer. El ejercicio aeróbico demostró mayores beneficios en el consumo de oxígeno, además de una alta adherencia, mientras que el entrenamiento de fuerza en una mayor capacidad específicamente en los miembros inferiores.
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    Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Guo, Rui; Yu, Qian; Liong, Emily C.; Fung, Man Lung; Tipoe, George L.
    Purpose. This study aimed to investigate the role of cathepsin B dependent autophagy induced by chronic aerobic exercise on a high-fat diet (HFD)- induced nonalcoholic steatohepatitis (NASH) in rats. Methods. Healthy female (Sprague-Dawley) SD rats (8- 10 weeks old; 180g-200g; n=6 per group) were divided into: (1) control group; (2) HFD group; (3) Exercise group; (4) HFD + exercise group. Rats were fed with a normal chow or an HFD for 12 weeks. Rats with exercise ran on a rotarod for 30 min per day from weeks 9-12. Results. Exercise training significantly (1) upregulated the levels of autophagy markers Beclin1, ATG5 and LC3II partly through inhibiting the p- AKT/mTOR pathway; (2) ameliorated HFD-mediated accumulation of fat mass by upregulating β-oxidation regulator PPAR-α and downregulating fatty acid synthesis marker SREBP-1c via lipophagy; (3) diminished the HFD-induced hepatic pro-inflammatory mediators TNF-α and IL-1β via NF-κB inactivation; (4) decreased the NASH-induced hepatic apoptotic marker caspase-3 activation caused by the upstream oxidative stress and by cytochrome P450 2E1 (CYP2E1); (5) mitigated the HFD-mediated lysosomal membrane permeabilisation and cathepsin B release partly via the reduction of reactive oxygen species (ROS). Conclusions. Chronic aerobic exercise reduces oxidative stress/ROS and ROS may cause lysosomal membrane destabilisation and disrupts the autophagic process. The beneficial effect of chronic exercise may further inhibit the process of lysosome membrane permeabilisation and facilitate lysosome fusion with autophagosomes to trigger autophagy. This process may possibly contribute to the inhibition of cathepsin B released into cytosol which further reduces inflammation and mitochondrial- dependent apoptosis.
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    Efecto del ejercicio físico sobre la memoria a corto plazo y velocidad en el procesamiento de información de un paciente que sufrió trauma craneoencefálico: Un caso de estudio
    (Murcia: Servicio de Publicaciones de la Universidad de Murcia, 2017) Salas Cabrera, Jorge; Herrera-González, Emmanuel; Garcés de los Fayos Ruiz, Enrique Javier; Herrera-Monge, M.F.; Brenes-Bolívar, J.; Monge-Ramos, J.; Facultades, Departamentos, Servicios y Escuelas::Facultades de la UMU::Facultad de Ciencias del Deporte
    En el artículo se presentan los resultados de un estudio mixto, realizado con un paciente adulto de 35 años de edad, diagnosticado con un trauma de cráneo contusión hemorrágica parietal izquierda superfcial focal. El propósito de esta investigación fue evidenciar el progreso de un pa- ciente masculino adulto que sufrió un trauma craneoencefálico al realizar ejercicio aeróbico, de contrarresistencia a la vez que realizaba entrenamiento cognitivo, por doce semanas y tres sesiones semanales. Los resultados mues- tran una mejora en el consumo máximo de oxigeno de un 30%, además a nivel cognitivo el paciente obtuvo mejoras en la velocidad de respuesta, así como de la respuesta a los comandos del token-test al fnalizar las 36 sesiones. Del mismo modo, las respuestas de la entrevista realizada a la esposa ante y después de la intervención muestran una mejora en la me- moria a corto plazo, en el procesamiento de la información y en el tiempo de respuesta. En conclusión, se puede apreciar la importancia que tiene las intervenciones de ejercicio físico aunadas al entrenamiento cognitivo, para mejorar el aspecto físico, cognitivo y emocional del paciente que sufre un trauma craneoencefálico, al mismo tiempo que se proporciona una mejora en la calidad de vida de la persona que participa de dicha intervención.
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    Moving in the right direction: Exploring the benefits of aerobic exercise in patients with recently elevated HbA1c levels
    (Universidad de Murcia. Servicio de Publicaciones, 2025) Mostafa Mohamed, Samir Abdel Latif; Said, Shereen Mohamed; El-Sayed, Mohamed Salah; Elnaggar, Moustafa Ibrahim Ahmed; Alakhras, Abdelhamid Mohamed Abdelhady; Mohamed Saleh, Marwa Mohamed Sayed; Metawee, Shimaa Mohamed; Elbedewy, Mohamed Ahmed; Sin departamento asociado
    Regular exercise is recognized as having health advantages for all individuals, inc luding enhancements in glycemic control, insulin efficacy, cardiovascular fitness, systemic inflammation, diabetes related health concerns, and mental well being. This study aimed to explore aerobic exercise benefits on patients with recently elevated HbA1c levels. A parallel, randomized controlled trial was conducted. A total of 60 participants were assigned to one of the two groups: The aerobic exercise (AE) Group and the Control group. Assessment included HbA1c (glycosylated hemoglobin), post prandial blood sugar (PPBS) as well as fasting blood sugar (FBS) at baseline (at 0 weeks before the training) and after the 12 weeks (post training). The results showed that in 12 weeks, the re was a statistically substantial difference in the two groups' mean values of HbA1c, PPBS, as well as FBS (p <0.001). Current research findings indicate that a 12 week protocol of aerobic exercise may serve as an essential therapeutic approach for achievi ng glycemic control in patients with recently elevated HbA1c levels.
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    The influence of 8 weeks of aerobic, strength and mixed exercises on the performance of short-term memory of women
    (Murcia: Servicio de Publicaciones de la Universidad de Murcia, 2019) Delir, Amanda; Mohammadi, Farzaneh
    The purpose of this study was to investigate the effect of 8 weeks of aerobic, strength and mixed exercise on short-term memory performance of women. It is a quasi-experimental study accomplished by a pre/post-test plan with three experimental groups and one control group. A total of 60 female volunteers were selected, randomly, allocated to four groups in-cluding: aerobic group, strength group, aerobic-strength group and control group. All the groups performed their training protocols. Measurement of short-term memory performance was done using memory span test in two steps pre and post of exercise sessions. Data was analyzed using dependent t-test and covariance test. Least significance difference (LSD) test was used to compare groups. The results suggest that 8 weeks of aerobic (p=0.001), strength (p=0.001) and strength-aerobic (0.029) exercise increases memory performance. The results of covariance test showed that 8 weeks of aerobic, strength and aerobic-strength exercise affect short-term memory of women differently. Also, the results of mean comparison test suggest that there is a significant difference between control, aerobic-strength and strength groups (p<0.05). Clinically speaking, these findings prove the importance of aerobic, strength, and aerobic-strength exercise in preserving and im-proving memory performance.