(Murcia: F. Hernández, 2011) Zhao Lieu, Zi; Gleeson, Paul A.
The trans-Golgi network (TGN) is a major
traffic hub of the cell, as it regulates membrane transport
in the secretory pathway as well as receiving protein
cargo by retrograde transport from endocytic
compartments. Retrograde transport between endosomes
and the TGN is essential for the recycling of membrane
proteins which regulate a range of cellular and
development functions. In addition, retrograde transport
pathways are exploited by many bacterial toxins to
mediate cytotoxicity and by some viral proteins to
promote pathogenicity. Recent advances using a range of
molecular cell biological strategies have identified
multiple retrograde transport pathways each regulated by
a distinct set of molecular machinery. Here we review
recent advances in this field and highlight the
importance of these transport pathways in a range of
physiological processes.