(Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Yu, Justine E; Han, Shu Yan; Wolfson, Benjamin; Zhou, Qun
Endothelial lipase (LIPG) plays a critical role
in lipoprotein metabolism, cytokine expression, and the
lipid composition of cells. Thus far, the extensive
investigations of LIPG have focused on its mechanisms
and involvement in metabolic syndromes such as
atherosclerosis. However, recent developments have
found that LIPG plays a role in cancer. This review
summarizes the field of LIPG study. We focus on the
role of LIPG in lipid metabolism and the inflammatory
response, and highlight the recent insights in its
involvement in tumor progression. Finally, we discuss
the potential of targeting LIPG in therapeutic strategies.