The Epidermal Growth Factor Receptor
(EGFR) is a member of the receptor tyrosine kinase
family and has important roles in development and
cancer. Through ligand stimulation, the EGFR initiates a
number of biochemical pathways that integrate to form
specific physiological responses. In addition to these
signaling pathways, the ligand stimulation also causes
the EGFR to internalize and be transported through the
endocytic pathway. The endocytic pathway regulates the
rate of EGFR degradation and recycling, as well as the
signaling mediated by the EGFR. In this review, the role
of rabs, a family of small molecular weight guanine
nucleotide binding proteins, is examined in how they
regulate endocytic trafficking