(Murcia : F. Hernández, 1999) Martí, R.; Gutierrez, A. ,; Peñafiel, A.; Marin-Padilla, M.; De la Calle, A.
The presence of Cajal-Retzius cells in the
adult human prefrontal and visual cortices has been
demonstrated with calcium binding protein immunocytochemistry
and NADPH-diaphorase histochemistry.
These cells expressed parvalbumin, calbindin and
calretinin calcium binding proteins and displayed
NADPH-diaphorase enzyme activity. The three basic
morphological profiles-horizontal, pyriform and
multipolar-were observed. The morphologies of labelled
cells resembled those of neurons observed in Golgi
studies of the human cerebral cortex. The presence of
calcium binding proteins and NADPH-diaphorase in
these cells suggests a possible inhibitory role as
GABAergic neurons. The persistence of Cajal-Retzius
cells in the adult cerebral cortex supports the idea that
they undergo developmental dilution rather than
postnatal degeneration.