(Murcia : F. Hernández, 2006) Shimada, K.; Nakamura, M.; Ishida, E.; Konishi, N.
Mitogen activated protein (MAP) kinases are
well known serine threonine kinases that modulate gene
expression, mitosis, cell proliferation and programmed
cell death or ‘apoptosis’ in response to various stresses.
Extracellular stress regulated kinase (ERK), c-jun NH2
terminal kinase and p38 are major members of the MAP
kinases, and there is now a body of evidence of their
involvement in genesis or sensitivity to chemotherapy of
human prostate cancers. In this review, we focus on the
molecular roles of MAP kinases and their pathological
correlations, with particular attention to novel
downstream signals through phosphorylation of the Fasassociated
death domain protein that effectively
regulates not only apoptosis but also the cell cycle in
prostate neoplastic cells.