Histology and histopathology Vol.34,nº12 (2019)

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Browsing Histology and histopathology Vol.34,nº12 (2019) by Author "Cui, Hong"

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    Potential therapeutic effect of SO2 on fibrosis.
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2019) Wang, Xin Bao; Cui, Hong; Du, Jun Bao
    Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO2), which can be generated endogenously in mammals, has been found to have vasorelaxation activity, improve cardiac function and decrease myocardial injury. Endogenous SO 2 also mediates the process of fibrosis. Inhibition of endogenous SO 2 can aggravate small pulmonary artery remodeling and abnormal collagen accumulation. SO 2 treatment significantly improves pulmonary fibrosis and pulmonary arterial remodeling. Overexpression of the key enzymes associated with endogenous SO 2 generation, aspartate aminotransferase (AAT) 1 and AAT2, mimics the effect of SO 2 on the down-regulation of collagen synthesis, while AAT1 or AAT2 knockdown aggravates abnormal collagen accumulation in vascular smooth muscle cells (VSMCs). SO 2 also improves myocardial fibrosis induced by myocardial infarction or diabetes in rats, and inhibits myocardial fibroblast proliferation and migration by the extracellular signal- regulated protein kinase pathway. The mechanisms underlying the inhibition of fibrosis by SO 2 are related to its antioxidant effect, anti-inflammation effect, improvement in cardiac function, and cell proliferation inhibition. Therefore, SO 2 has a potential therapeutic effect on fibrosis.