(Murcia : F. Hernández, 2000) Belanger, I.; Beaulieu, J.F.
The tenascins are a family of multifunctional
extracellular matrix glycoproteins subject to complex
spatial and temporal patterns of expression in the course
of various organogenetic processes, namely those
involving epithelial-mesenchymal interactions. In the
intestine, the tenascins, in particular tenascin-C, have
been found to be differentially expressed in the
developing and adult small intestinal and colonic mucosa
as well as in neoplasm. While tenascin-C emerges as a
key player likely to be involved in intestinal mucosa
development, maintenance and disease, its exact role in
the regulation of fundamental intestinal cell function(s)
such as proliferation, migration and tissue-specific gene
expression remains however to be established.