Histology and histopathology Vol.19, nº 4 (2004)

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Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization
(Murcia : F. Hernández, 2004) Sills, E.S.; Ghulmiyyah, L.M.; Wehbe, S.A.; Atkinson, P.F.; Perloe, M.; Tucker, M.J.
The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.