(Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Zhang, Julei; Li, Yan; Bai, Xiaozhi; Li, Yuehua; Shi, Jihong; Hu, Dahai
Hypertrophic scars (HTS) are predominant
diseases after burn and trauma, which cause severe
physiological and psychological problems. HTS have
been researched for decades, and our knowledge about
the mechanisms of HTS formation process has been
increasing. However, the effects of currently available
prevention and treatment strategies are limited. In this
review, we summarize currently known mechanisms and
recent studies of HTS, including extracellular matrix,
matrix metalloproteinases, fibroblasts, myofibroblasts
and their contraction ability, keratinocytes, growth
factors, inflammatory and immune response, and stem
cell treatment, hoping for a better understanding of HTS
generation, development and effective translation to
treatment strategies.