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Título: | Localization of human placental glucose transporter 1 during pregnancy. An immunohistochemical study |
Fecha de publicación: | 1996 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetricia |
Palabras clave: | Placenta Human |
Resumen: | To elucidate the potential roles of glucose transporter 1 (GLUTl) in human placenta during pregnancy, we examined the localization of GLUTl in human placenta at various stages by immunohistochemistry with an anti-GLUT1 antibody by use of both light and electron microscopy. Specific staining for GLUTl was localized on the apical brush border and along the basal plasma membrane of the syncytiotrophoblasts. The staining at the apical side was more intense than that at the basal side during the early stages of gestation. In later gestational stages, however, the staining pattern at the apical side became blurred and the staining intensity at the basal side increased. The cytotrophoblasts, seen embedded in the basal part of the syncytiotrophoblasts, seemed to show immunoreactivity for GLUTl along the plasma membranes at the lightmicroscopic level. However, immuno-electron microscopic analysis with either pre- or post-embedding methods revealed that specific staining for GLUTl was hardly observed on the cytotrophoblasts, but the cytotrophoblasts were often surrounded by immunoreactive processes of syncytiotrophoblasts. The blood capillaries and erythrocytes in the stroma of placental villi were always immunoreactive for GLUTl throughout pregnancy. These findings suggest that GLUTl may play a vital role in human pregnancy. |
Autor/es principal/es: | Tadokoro, C. Yoshimoto, Y. Sakata, M. Fujimiya, M. Kurachi, H. Adachi, E. Maeda, T. Miyake, A. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18857 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.11, nº 3 (1996) |
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Localization of human placental glucose transporter 1 during pregnancy. An immunohistochemical study.pdf | 5,12 MB | Adobe PDF | Visualizar/Abrir |
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