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dc.contributor.authorde Souza, Paula Aiello Tomé-
dc.contributor.authorde Souza, Rodrigo Wagner Alves-
dc.contributor.authorCampos Soares, Luana-
dc.contributor.authorPiedade, Warlen Pereira-
dc.contributor.authorCampos, Dijon Henrique S.-
dc.contributor.authorCarvalho, Robson Francisco-
dc.contributor.authorPadovani, Carlos Roberto-
dc.contributor.authorOkoshi, Katashi-
dc.contributor.authorCicogna, Antônio Carlos-
dc.contributor.authorMichelin Matheus, Selma Maria-
dc.contributor.authorDal-Pai-Silva, Maeli-
dc.identifier.citationHistology and Histopathology, vol. 30, nº 7, (2015)es
dc.description.abstractIntroduction: Heart failure (HF) is a progressive myopathy, with clinical signs of fatigue and limb weakness that can damage the nerve-muscle interaction, altering synaptic transmission and nicotinic acetylcholine receptors (nAChR) in neuromuscular junctions (NMJs). The diaphragm is composed of a mixed proportion of muscle fibres, and during HF, this muscle becomes slower and can alter its function. As exercise training is an accepted practice to minimise abnormalities of skeletal muscle during HF, in this study, we evaluated the hypothesis that aerobic training attenuates alterations in the expression of nAChR subunits in NMJs diaphragm during heart failure. Objective: The aim of this study was to evaluate the distribution and expression of nAChR subunits in the diaphragm muscle fibres of rats subjected to an aerobic training programme during HF. Methods: Control (Sham), control training (ShamTR), aortic stenosis (AS) and aortic stenosis training (ASTR) groups were evaluated. The expression of nAChR subunits (γ, α1, ε, β1 and δ) was determined by qRT-PCR, and NMJs were analysed using confocal microscopy. Results: We observed increased expression of the γ, α1 and β1 subunits in the AS group compared with the ASTR group. The distribution of NMJs was modulated in these groups. Discussion: HF alters the mRNA expression of nAChR subunits and the structural characteristics of diaphragm NMJs. In addition, aerobic training did notalter NMJs morphology but attenuated the alterations in heart structure and function and in nAChR subunit mRNA expression. Our findings demonstrate the beneficial effects of aerobic exercise training in maintaining the integrity of the neuromuscular system in the diaphragm muscle during HF and may be critical for non-pharmacological therapy to improve the quality of life for patients with this syndrome.es
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectSkeletal musclees
dc.subjectHeart failurees
dc.subjectAerobic traininges
dc.subjectNeuromuscular junctiones
dc.subjectNicotinic acetylcholine receptorses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAerobic training attenuates nicotinic acetylcholine receptor changes in the diaphragm muscle during heart failurees
Aparece en las colecciones:Vol.30, nº7 (2015)

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