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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Kourea, Helen P. | - |
dc.contributor.author | Kotoula, Vassiliki | - |
dc.contributor.author | Koutras, Angelos | - |
dc.contributor.author | Alexopoulou, Zoi | - |
dc.contributor.author | Papaspirou, Irene | - |
dc.contributor.author | Skarlos, Dimosthenis V. | - |
dc.contributor.author | Efstratiou, Ioannis | - |
dc.contributor.author | Bobos, Mattheos | - |
dc.contributor.author | Zagouri, Flora | - |
dc.contributor.author | Papakostas, Pavlos | - |
dc.contributor.author | Pectasides, Dimitrios | - |
dc.contributor.author | Chrisafi, Sofia | - |
dc.contributor.author | Varthalitis, Ioannis | - |
dc.contributor.author | Aravantinos, Gerasimos | - |
dc.contributor.author | Kosmidis, Paris | - |
dc.contributor.author | Bafaloukos, Dimitrios | - |
dc.contributor.author | Scopa, Chrisoula D. | - |
dc.contributor.author | Fountzilas, George | - |
dc.date.accessioned | 2020-09-24T17:39:48Z | - |
dc.date.available | 2020-09-24T17:39:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Histology and histopathology, Vol. 30, nº 9 (2015) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/96466 | - |
dc.description.abstract | Background: Metronomic taxane administration has putative antiangiogenic properties. Herein, we examined the baseline tumor angiogenic profile of patients with metastatic breast carcinoma (MBC) in a prospective-retrospective translational research study. The interplay between the angiogenic factors expressed in the tumors and their prognostic value in MBC were investigated. Patients and Methods: Tumor tissues from patients with MBC treated with weekly docetaxel (n=159) were examined by immunohistochemistry for VEGF-A, VEGF-C, VEGFR-1, VEGFR-2, VEGFR-3 and osteopontin (OPN) and by mRNA analysis for expression of VEGF-A, VEGFxxxa, VEGFxxxb, VEGFC, thrombospondin-1 (THBS-1), hypoxia-inducible factor-1α (HIF-1α) and von Hippel-Lindau (VHL) genes. Associations between these parameters and outcome were statistically analyzed. Results: Statistically significant correlations were identified between almost all biomarkers examined in continuous form, particularly at the mRNA level: VEGFA with VEGFxxxa (rho=0.70); VEGF-C with VEGFxxxa, VEGFxxxb and VHL (rho=0.51, 0.60 and 0.44 respectively); HIF-1α with VEGF-C and THBS1 (rho=0.48 and 0.45). High VEGF-A mRNA was associated with worse survival (p=0.0279) and marginally with progression free survival (PFS). Intratumoral co-expression of VEGFR-1 and VEGFR-2 proteins was associated with more favorable survival (p=0.0337). In multivariate analysis, only high VEGF-A mRNA levels retained their prognostic role for worse PFS and survival (PFS: HR=2.34, 95% CI=1.25-4.40, p=0.0080; survival: HR=3.15, 95% CI=1.48-6.72, p=0.0029). Conclusions: In MBC, this study confirms the adverse prognostic effect of high intratumoral VEGF-A mRNA and reveals the combined VEGFR-1/VEGFR-2 protein expression as a potentially favorable prognosticator, which merits further evaluation in larger studies. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Metastatic breast cancer | es |
dc.subject | Docetaxel | es |
dc.subject | VEGFA | es |
dc.subject | VEGFR-1 | es |
dc.subject | VEGFR-2 | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Impact of tumor angiogenic profile on the outcome of patients with metastatic breast carcinoma treated with weekly docetaxel. A Hellenic Cooperative Oncology Group (HeCOG) study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-11-612 | - |
Aparece en las colecciones: | Vol.30, nº9 (2015) |
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Impact of tumor angiogenic profile on the.pdf | 1,27 MB | Adobe PDF | Visualizar/Abrir |
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