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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Fernandes, Luanna Melo Pereira | - |
dc.contributor.author | Teixeira, Francisco Bruno | - |
dc.contributor.author | Junior, Sergio Melo Alves | - |
dc.contributor.author | Pinheiro, João de Jesus Viana | - |
dc.contributor.author | Maia, Cristiane Socorro Ferraz | - |
dc.contributor.author | Lima, Rafael Rodrigues | - |
dc.date.accessioned | 2020-09-23T16:58:24Z | - |
dc.date.available | 2020-09-23T16:58:24Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Histology and histopathology, Vol. 30, nº 9 (2015) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/96401 | - |
dc.description.abstract | Alcoholism in humans is a chronic and progressive disease, characterized by loss of ethanol consumption control. Previous studies have reported that prolonged exposure to ethanol was responsible for alterations in glandular tissues of human and rodents. However, the interrelationship between ethanol and the glandular system is still the subject of numerous investigations, including the possible resistance of the submandibular gland (SG). In the present study, we investigated whether chronic ethanol exposure during adolescence may affect the parotid gland (PG) and SG in female rats. Female rats (n=16) were treated with distilled water or ethanol (dose of 6.5 g/kg/day, 22.5% w/v) through gavage for 55 days. Glands were collected, weighed and submitted to histological processing. Morphometric analysis was assessed by parenchymal and stromal area measurements. Smooth muscle actin (α-SMA), cytokeratin-19 (CK19) and apoptotic caspase3 (CAS) were measured using ImageJ® software. Chronic ethanol administration did not alter the body weight of rats after treatment, although it increased glandular weight (p<0.001), reduced the parenchyma area (p<0.001) and decreased CK19 and α-SMA immunostainning in the PG. Besides, ethanol induced CK19 and CAS overexpression, and the occurrence of duct-like structures in SG. These results suggest that ethanol induces histological and morphometric changes in salivary glands of female rats intoxicated with ethanol during adolescence. Furthermore, the mechanism underlying these alterations needs to be investigated but may be not related to the inflammatory process. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ehanol | es |
dc.subject | Salivary glands | es |
dc.subject | Immunohistochemistry | es |
dc.subject | Adolescence | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Immunohistochemical changes and atrophy after chronic ethanol intoxication in rat salivary glands | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-11-604 | - |
Aparece en las colecciones: | Vol.30, nº9 (2015) |
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Immunohistochemical changes and atrophy after.pdf | 10,46 MB | Adobe PDF | Visualizar/Abrir |
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