Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-11-602

Título: Novel features of neurodegeneration in the inner retina of early diabetic rats
Fecha de publicación: 2015
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and histopathology, Vol. 30, nº 8 (2015)
ISSN: 1699-5848
Materias relacionadas: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Palabras clave: Neurodegeneration
Diabetic retinopathy
Glial reactivity
Calcium binding proteins
Resumen: The literature indicates that in diabetes retinal dysfunctions related to neural retinal alterations exist prior to clinically detectable vasculopathy. In a previous report, a detailed description about the alteration of the outer retina was given, where diabetic degeneration preceded apoptotic loss of cells (Enzsöly et al., 2014). Here, we investigated the histopathology of the inner retina in early diabetes using the same specimens. We examined rat retinas with immunohistochemistry and Western blotting, 12 weeks after streptozotocin induction of diabetes. Glial reactivity was observed in all diabetic retinal specimens; however, it was not detectable all over the retina, but appeared in randomly arranged patches, with little or no glia activation in between. Similarly, immunoreactivity of parvalbumin (staining mostly AII amacrine cells) was also decreased only in some regions. We propose that these focal changes appear prior to affecting the whole retina and overt loss of cells. In contrast to these, most other markers used (calretinin, recoverin, tyrosin hydroxylase anti-Brn-3a and also calbindin in the optic part of the retina) did not show any major alterations in the intensity of immunoreactivity or in the number of stained elements. Interestingly, under diabetic conditions, the labeling pattern of PKC-α and calbindin in the ciliary retina showed a clear resemblance to the pattern described during development. This observation is in line with our previous study, reporting an increase in the number of dual cones, coexpressing two photopigments, which is another common feature with developing retinas. These data may indicate a previously uninvestigated regenerative capacity in diabetic retina
Autor/es principal/es: Énzsöly, Anna
Szabó, Arnold
Szabó, Klaudia
Szél, Ágoston
Németh, János
Lukáts, Ákos
URI: http://hdl.handle.net/10201/96343
DOI: https://doi.org/10.14670/HH-11-602
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 15
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Aparece en las colecciones:Vol.30, nº8 (2015)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Novel features of neurodegeneration.pdf19,97 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons