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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Buján, J. | - |
dc.contributor.author | Jurado, F. | - |
dc.contributor.author | Gimeno, M. J. | - |
dc.contributor.author | Rodriguez, M. | - |
dc.contributor.author | Bellón, J. M. | - |
dc.date.accessioned | 2020-09-04T15:19:28Z | - |
dc.date.available | 2020-09-04T15:19:28Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Histology and Histopathology, Vol. 16, n.º 1 (2001) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/95721 | - |
dc.description.abstract | The role of Sandimmun Neoral® (S-n) and the immune response in transplant-associated coronary vasculopathy (TACV) was evaluated in a Lewis (Lew)- to-Fischer-344 (F344) rat abdominal heterotopic heart transplant model. Some of the transplant recipients were treated with S-n (5mg/ kg/ day) for 14 days posttransplant, or until sacrifice. Grafts were subjected to immunohistochemical (ED1, CD4, CD8 and a-actin+ cells) anal ysis from day 7 to 100 post-transplant. Singenic controls did not develop TACV, irrespective of whether they had received the drug or not. TACV was detected in Lew-F344 transplants regardless of S-n administration with participation of ED1+, CD8+ and aactin+ cells, although its incidence was lower in animals receiving prolonged S-n treatment. In this model, accelerated arteriosclerosis of the graft appeared to be related more to the rejection effect than to the action of the immunosuppressive agent. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Heart transplant | es |
dc.subject | Coronary vasculopathy | es |
dc.subject | Sandimmun neoral | es |
dc.subject | Inflammatory cells | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Function of inflammatory cells and neoral cyclosporin-A in heart transplant-associated coronary vasculopathy | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.16, nº 1 (2001) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Function of inf lammatory cells and neoral cyclosporin-A in heart transplant-associated coronary .pdf | 4,26 MB | Adobe PDF | Visualizar/Abrir |
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