Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/95712
Twittear
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Trejter, M. | - |
dc.contributor.author | Warchol, J. B. | - |
dc.contributor.author | de Caro, R. | - |
dc.contributor.author | Brelinska, R. | - |
dc.contributor.author | Nussdorfer, G. G. | - |
dc.contributor.author | Malendowicz, L. K. | - |
dc.date.accessioned | 2020-09-04T14:19:32Z | - |
dc.date.available | 2020-09-04T14:19:32Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Histology and Histopathology, Vol. 16, n.º1 (2001) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/95712 | - |
dc.description.abstract | The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation ha s been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors of the three neuropeptides on the mitotic index (%0 of metaphase-arrested cells after vincristin injection) of thymocytes. Both CCK- and TN-receptor antagonists were ineffective. In contrast, two VIP receptor antago nists (VIP-As) enhanced the mitotic index of thymocytes. VIP reversed the effect of VIP-As, but when administered alone it did not alter the mitotic activity of thymocytes. In light of these findings, we conclude that endogenous VIP exerts a maximal tonic inhibitory influence on the basal proliferative activity of rat thymocytes, while endogenous CCK and NT do not play a relevant modulatory role in thi process. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Thymus | es |
dc.subject | Cell proliferation | es |
dc.subject | Vasoactive intestinal peptide | es |
dc.subject | Cholecystokinin | es |
dc.subject | Neurotensin | es |
dc.subject | Rat | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología | es |
dc.title | Studies on the involvement Histology and Histopathology Cellular and Molecular Biology of endogenous neuropeptides in the control of thymocyte proliferation in the rat | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.16, nº 1 (2001) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation .pdf | 2,4 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons