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Título: | Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study |
Fecha de publicación: | 1998 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and histopathology, Vol.13, nº 1 (1998) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Prolonged myocardial preservation Cape Town solution Continuous perfusion Reperfusion Injury |
Resumen: | This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic findings after orthotopic heart transplantation in dogs. After preservation, aside from mild or moderate mitochondrial changes, the most relevant lesions included edema and vasoconstriction. Reperfusion was followed by the development of areas of necrosis forming contraction bands and an increment in the mitochondrial damage ; the intercalated disks conserved their normal structure; edema became more prominent and was in variably accompanied by hemorrhage; vasoconstriction was very pronounced and was accompanied on occasion by evidence of capillary rupture; and inflammatory cells were observed in the interstitium. These results indicate that colloid must be added to Cape Town solution and that reperfusion probably requires selective approaches to deal with vasoconstriction and inflammation. |
Autor/es principal/es: | García Poblete, E. Alvárez, L. Fernández, H. Escudero, C. Torralba, A. |
URI: | http://hdl.handle.net/10201/92454 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.13, nº 1 (1998) |
Ficheros en este ítem:
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Cape Town solution in prolonged myocardial preservation, structural and ultrastructural study.pdf | 1,49 MB | Adobe PDF | Visualizar/Abrir |
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