Comunicaciones Orales.-Effects of Endocrine Disruptors Chemicals on the immune response of gilthead seabream (Sparus aurata L.)

Abstract

ABSTRACT Endocrine disruptors chemicals (EDCs) exert their effects via agonistic/antagonistic interactions with hormone receptors or by interfering with the normal synthesis, transport, metabolism, and secretion of endogenous hormones [1]. EDCs, from the pharmaceutical industry, such as 17α-ethinylestradiol (EE2) and tamoxifen (Tmx,), have been founded in the aquatic environment. EE2 is used in most oral contraceptive pills and in hormone replacement therapy, while Tmx is an estrogen receptor ligand used in cancer therapy. This study aims to investigate the effects of the dietary intake of EE2 (5 μg/g food) or Tmx (100 μg/g food) on the immune response of gilthead seabream species, a marine protandrous teleost, with a great commercial value in the Mediterranean area.