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dc.contributor.authorFerrero, Stefano-
dc.contributor.authorVaira, Valentina-
dc.contributor.authorDel Gobbo, Alessandro-
dc.contributor.authorVicentini, Leonardo-
dc.contributor.authorBosari, Silvano-
dc.contributor.authorBeck-Peccoz, Paolo-
dc.contributor.authorMantovan, Giovanna-
dc.contributor.authorSpada, Anna-
dc.contributor.authorLania, Andrea G.-
dc.date.accessioned2020-03-30T11:46:44Z-
dc.date.available2020-03-30T11:46:44Z-
dc.date.issued2015-
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 4 (2015)es
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/88941-
dc.description.abstractThe four regulatory subunits (R1A, R1B, R2A, R2B) of protein kinase A (PKA) are differentially expressed in several cancer cell lines and exert distinct roles in both cell growth and cell differentiation control. Mutations of the PRKAR1A gene have been found in patients with Carney complex and in a minority of sporadic anaplastic thyroid carcinomas. The aim of the study was to retrospectively evaluate the expression of different PKA regulatory subunits in benign and non benign human thyroid tumours and to correlate their expression with clinical phenotype. Immunohistochemistry demonstrated a significant increase in PRKAR2B expression in both differentiated and undifferentiated (anaplastic) thyroid tumors in comparison with normal thyroid tissues. Conversely, a significant increase in PRKAR1A expression was only demonstrated in undifferentiated thyroid carcinomas in comparison with normal thyroid tissue and differentiated thyroid tumors. In thyroid cancers without lymph nodal metastases PRKAR1A expression was higher in tumours of more than 2 cm in size (T2 and T3) compared to smaller ones (T1). In conclusion, our data shows that an increased PRKAR1A expression is associated with aggressive and undifferentiated thyroid tumors.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPKAes
dc.subjectThyroid neoplasiaes
dc.subjectPRKAR1Aes
dc.subjectPRKAR2Bes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleDifferent expression of protein kinase A (PKA) regulatory subunits in normal and neoplastic thyroid tissueses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttp://doi.org/10.14670/HH-30.473-
Aparece en las colecciones:Vol.30, nº4 (2015)

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