Please use this identifier to cite or link to this item: https://doi.org/10.14670/HH-30.413

Title: Small cell carcinoma of the prostate: Molecular basis and clinical implications
Issue Date: 2015
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Citation: Histology and Histopathology, Vol. 30, n.º 4 (2015)
ISSN: 1699-5848
0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Prostatic small cell carcinoma
Androgen receptor
TMPRSS2-ERG rearrangement
Clonal origin
Abstract: Small cell carcinoma of the prostate (PSCC) is a rare and highly aggressive malignancy with a dismal prognosis. Most patients present with advanced disease, including metastases to bone, viscera, and the central nervous system. Histologically, PSCC is indistinguishable from its pulmonary counterpart. Although PSCC may occur in pure form, as in small cell lung carcinoma, it also occurs in conjunction with conventional glandular prostate carcinoma, and may evolve from conventional adenocarcinoma during the course of hormonal therapy. Immunohistochemical staining is extremely helpful in establishing the diagnosis, a prerequisite, as in small cell lung cancer, for optimal therapeutic strategy. Currently, combinations of surgical resection, chemotherapy, and radiation therapy represent the main treatment options. Improvement in survival may depend upon the identification of new molecular markers to facilitate earlier diagnosis and the development of novel targeted therapies. This review will discuss general aspects of PSCC, focusing on ways in which our understanding of PSCC has been advanced by studies of the histopathologic, immunohistochemical and molecular alterations in this disease.
Primary author: Wang, Lisha
Davidson, Darrell D.
Montironi, Rodolfo
Lopez-Beltran, Antonio
Zhang, Shaobo
Williamson, Sean R.
MacLennan, Gregory T.
Wang, Chaofu
Wang, Mingsheng
Emerson, Robert E.
Du, Xiang
Cheng, Liang
URI: http://hdl.handle.net/10201/88726
DOI: https://doi.org/10.14670/HH-30.413
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 12
Rights: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Vol.30, nº4 (2015)

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