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Título: | Current understanding of orofacial tissue derived mesenchymal stem cells: an immunological perspective |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol. 30, n.º 3 (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología |
Palabras clave: | Mesenchymal stem cells Tooth Immunomodulation Cell therapy |
Resumen: | Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic progenitor cells able to differentiate into multiple lineages, holding the potential for replacing damaged and diseased tissues by tissue regeneration and immunomodulatory functions. So far, MSCs have been successfully isolated and characterized from a variety of orofacial tissues, including dental pulp, periodontal ligament, root apical papilla, gingiva, etc. In addition to their self-renewal and multipotent differentiation properties, these orofacial tissue derived MSCs are also capable of profound immunomodulatory effects in vitro and in vivo, thus providing a foundation for their utilization in allogeneic application and in treating autoimmune diseases and inflammatory disorders. In this paper, we will review the current research progress of the immunomodulatory properties of orofacial tissue derived MSCs and the underlying mechanisms, emphasizing the effect of these MSCs on immune cells, which will facilitate the use of such cells in clinical treatment. |
Autor/es principal/es: | Ding, Gang Niu, Jianyi Wei, Fulan |
URI: | http://hdl.handle.net/10201/88074 |
DOI: | Https://doi.org/10.14670/HH-30.255 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30, nº3 (2015) |
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