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Título: | BCR-ABL negative myeloproliferative neoplasia: a review of involved molecular mechanisms |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol. 30, n.º 2 (2015) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología |
Palabras clave: | Myeloproliferative neoplasia Essential thrombocythaemia Polycythemia vera Primary myelofibrosis |
Resumen: | The clonal bone marrow stem cell disorders essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) belong to the group of Philadelphia chromosome negative myeloproliferative neoplasia (Ph- MPN). In 2005 the JAK2V617F mutation was discovered which has generated more insight in the pathogenetic mechanism of the MPNs. More mutations have been detected in MPN patients since. However, the underlying cause of MPN has not been discovered so far. The mechanism of increased angiogenesis in MPNs and the development of fibrosis in the bone marrow in PMF patients and in some ET and PV patients is still not known. This review will focus on the most important molecular pathogenetic mechanisms in MPN patients. |
Autor/es principal/es: | Koopmans, Suzanne M. Schouten, Harry C. van Mario, Ariënne M.W. |
URI: | http://hdl.handle.net/10201/86457 |
DOI: | https://doi.org/10.14670/HH-30.151 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30, nº2 (2015) |
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Koopmans-30-151-161-2015.pdf | 3,35 MB | Adobe PDF | Visualizar/Abrir |
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