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dc.contributor.authorCoelho, Carly Faria-
dc.contributor.authorVieira, Rodolfo P.-
dc.contributor.authorLopes-Martins, Patrícia Sardinha Leonardo-
dc.contributor.authorTeixeira, Simone Aparecida-
dc.contributor.authorBorbely, Alexandre Urban-
dc.contributor.authorGouvea, Irene María-
dc.contributor.authorFrigo, Lucio-
dc.contributor.authorLopes-Martins, Rodrigo Álvaro Brandão-
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 1 (2015)es_ES
dc.description.abstractInhaled nitric oxide therapy reaches not only pulmonary vessels, but also other vasculatures, presenting anti-inflammatory effects. Therefore, this study investigated the effects of inhaled nitric oxide on a mice model of carrageenan-induced paw edema. Paw edema was induced in male Swiss mice (20-30 g) by subplantar injection of carrageenan (0.05 ml of a 1% suspension in 0.9% saline). The evaluation of timecourse edema (mililiter) was measured by plethysmometry until 12 h following carrageenan administration. Thirty minutes after carrageenan injection, some groups received inhaled nitric oxide (300 ppm at variable doses and times) or Indometacin (INDO 5 mg/Kg, v.o), while others received sildenafil (1 mg/Kg, i.p) or rolipram (3 mg/Kg, i.p.) with or without inhaled nitric oxide. Paws were assessed for edema levels by plethysmometry, mieloperoxidase activity and histological analysis. Inhaled nitric oxide significantly reduced carrageenan-induced paw edema, mieloperoxidase activity and inflammatory infiltrate, although similar results were also observed in sildenafil and rolipram treated groups. In addition, significant effects between inhaled nitric oxide with pharmacological therapy was observed. Inhaled nitric oxide presents anti-inflammatory effects on carrageenaninduce paw edema, as observed through reduced edema, mieloperoxidase activity and neutrophil infiltration, indicating that inhaled nitric oxide therapy goes beyond lung vascular effects.es_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectInhaled nitric oxidees_ES
dc.subjectPaw edemaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes_ES
dc.titleThe effect of inhaled nitric oxide on the carrageenan-induced paw edemaes_ES
Appears in Collections:Vol.30, nº1 (2015)

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