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dc.contributor.authorMusumeci, Giuseppe-
dc.contributor.authorSzychlinska, Marta Anna-
dc.contributor.authorMobasheri, Ali-
dc.date.accessioned2020-01-28T15:38:29Z-
dc.date.available2020-01-28T15:38:29Z-
dc.date.issued2015-
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 1 (2015)es_ES
dc.identifier.issn1699-5848-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/10201/86134-
dc.description.abstractAging is a natural process by which every single living organism approaches its twilight of existence in a natural way. However, aging is also linked to the pathogenesis of a number of complex diseases. This is the case for osteoarthritis (OA), where age is considered to be a major risk factor of this important and increasingly common joint disorder. Half of the world's population, aged 65 and older, suffers from OA. Although the relationship between the development of OA and aging has not yet been completely understood, it is thought that age-related changes correlate with other risk factors. The most prominent hypothesis linking aging and OA is that chondrocytes undergo premature aging due to several factors, such as excessive mechanical load or oxidative stress, which induce the so called “stress-induced senescent state”, which is ultimately responsible for the onset of OA. This review focuses on molecular markers and mechanisms implicated in chondrocyte aging and the pathogenesis of OA. We discuss the most important age-related morphological and biological changes that affect articular cartilage and chondrocytes. We also identify the main senescence markers that may be used to recognize molecular alterations in the extracellular matrix of cartilage as related to senescence. Since the aging process is strongly associated with the onset of osteoarthritis, we believe that strategies aimed at preventing chondrocyte senescence, as well as the identification of new increasingly sensitive senescent markers, could have a positive impact on the development of new therapies for this severe disease.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.languageenges_ES
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOsteoarthritises_ES
dc.subjectAginges_ES
dc.subjectCartilagees_ES
dc.subjectChondrocytees_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes_ES
dc.titleAge-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocyteses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttps://doi.org/10.14670/HH-30.1-
Aparece en las colecciones:Vol.30, nº1 (2015)

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