Please use this identifier to cite or link to this item: https://doi.org/10.14670/HH-29.1525

Title: Therapeutic implications of melatonin in cerebral edema
Issue Date: 2014
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Citation: Histology and Histopathology, Vol. 29, n.º 12 (2014)
ISSN: 0213-3911
1699-5848
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Cerebral edema
Melatonin
Cytotoxic cerebral edema
Vasogenic cerebral edema
Abstract: Cerebral edema/brain edema refers to the accumulation of fluid in the brain and is one of the fatal conditions that requires immediate medical attention. Cerebral edema develops as a consequence of cerebral trauma, cerebral infarction, hemorrhages, abscess, tumor, hypoxia, and other toxic or metabolic factors. Based on the causative factors cerebral edema is differentiated into cytotoxic, vasogenic, osmotic and interstitial cerebral edema. Treatment of cerebral edema depends on timely diagnosis and medical assistance. Pragmatic treatment strategies such as antihypertensive medications, nonsteroidal anti-inflammatory drugs, barbiturates, steroids, glutamate and N-methyl-Daspartate receptor antagonists and trometamol are used in clinical practice. Although the above mentioned treatment approaches are being used, owing to the complexity of the mechanisms involved in cerebral edema, a single therapeutic strategy which could ameliorate cerebral edema is yet to be identified. However, recent experimental studies have suggested that melatonin, a neurohormone produced by the pineal gland, could be an effective alternative for treating cerebral edema. In animal models of stroke, melatonin was not only shown to reduce cerebral edema but also preserved the blood brain barrier (BBB) integrity. Melatonin’s beneficial effects were attributed to its properties, such as being a potent anti-oxidant, and its ability to cross the BBB within minutes after its administration. This review summarizes the beneficial effects of melatonin when used for treating cerebral edema.
Primary author: Rathnasamy, Gurugirijha
Ling, Eng-Ang
Kaur, Charanjit
URI: http://hdl.handle.net/10201/84822
DOI: https://doi.org/10.14670/HH-29.1525
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 14
Rights: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Vol.29, nº12 (2014)

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