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https://doi.org/10.14670/HH-29.1499
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Título: | Metastatic dormancy: a complex network between cancer stem cells and their microenvironment |
Fecha de publicación: | 2014 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol. 29, n.º 12 (2014) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Metastatic niche Extracellular matrix Therapy resistance |
Resumen: | Metastasis represents the major threat of cancer progression and generally emerges years after the detection of the primary tumor. An important ratelimiting step resides in cellular dormancy, where a disseminated tumor cell remains in a quiescent state at a remote organ. Herein we review the molecular mechanisms leading to tumor dormancy, mainly in regards to cellular quiescence and the tumor microenvironment. Based on the current published literature, we provide evidence that links the cancer stem cell (CSC) theory with dormancy and metastasis. Once a disseminated tumor cell reaches a target tissue, a tight regulation imposed by the foreign microenvironment will dictate the fate of these cells, which implies a balance in the secretion of soluble factors, modulation of the extracellular matrix and the angiogenic switch. We investigate thoroughly whether the CSC theory could also apply to metastasis initiation. In fact, the resistance of CSCs to therapy, leading to the minimal residual disease and cellular quiescence phenotypes, predisposes for the development of metastases. Finally, we describe the new technologies available for the identification of circulating tumor cells (CTCs), as well as their clinical relevance in dormancy of metastatic cancer patients. |
Autor/es principal/es: | Bleau, Anne-Marie Agliano, Alice Larzabal, Leyre Lopez de Aberasturi, Arrate Calvo, Alfonso |
URI: | http://hdl.handle.net/10201/84821 |
DOI: | https://doi.org/10.14670/HH-29.1499 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.29, nº12 (2014) |
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Fichero | Descripción | Tamaño | Formato | |
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Bleau-29-1499-1510-2014.pdf | 1,26 MB | Adobe PDF | Visualizar/Abrir |
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