Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-29.1499

Título: Metastatic dormancy: a complex network between cancer stem cells and their microenvironment
Fecha de publicación: 2014
Editorial: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, Vol. 29, n.º 12 (2014)
ISSN: 0213-3911
Materias relacionadas: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Metastatic niche
Extracellular matrix
Therapy resistance
Resumen: Metastasis represents the major threat of cancer progression and generally emerges years after the detection of the primary tumor. An important ratelimiting step resides in cellular dormancy, where a disseminated tumor cell remains in a quiescent state at a remote organ. Herein we review the molecular mechanisms leading to tumor dormancy, mainly in regards to cellular quiescence and the tumor microenvironment. Based on the current published literature, we provide evidence that links the cancer stem cell (CSC) theory with dormancy and metastasis. Once a disseminated tumor cell reaches a target tissue, a tight regulation imposed by the foreign microenvironment will dictate the fate of these cells, which implies a balance in the secretion of soluble factors, modulation of the extracellular matrix and the angiogenic switch. We investigate thoroughly whether the CSC theory could also apply to metastasis initiation. In fact, the resistance of CSCs to therapy, leading to the minimal residual disease and cellular quiescence phenotypes, predisposes for the development of metastases. Finally, we describe the new technologies available for the identification of circulating tumor cells (CTCs), as well as their clinical relevance in dormancy of metastatic cancer patients.
Autor/es principal/es: Bleau, Anne-Marie
Agliano, Alice
Larzabal, Leyre
Lopez de Aberasturi, Arrate
Calvo, Alfonso
URI: http://hdl.handle.net/10201/84821
DOI: https://doi.org/10.14670/HH-29.1499
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 12
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Aparece en las colecciones:Vol.29, nº12 (2014)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Bleau-29-1499-1510-2014.pdf1,26 MBAdobe PDFVista previa

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons