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Title: | The biological role of Treg cells in ectopic endometrium homeostasis |
Issue Date: | 2014 |
Publisher: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Citation: | Histology and Histopathology, vol. 29, nº 10, (2014) |
ISSN: | 1699-5848 0213-3911 |
Related subjects: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología CDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetricia |
Keywords: | Endometriosis Treg Immune tolerance |
Abstract: | Although retrograde menstruation is observed in up to 90% of women, endometriosis actually develops in only15% of women. There is considerable evidence in the literature that ectopic endometrial cells are able to evade immune surveillance and that the immune response in the microenvironment of ectopic lesions is limited. Endometriosis develops when a deficiency in the local immune response has been generated, and progression of the disease is related to the intensity of this process. Over the last couple of decades it has been well known that T regulatory lymphocytes (Tregs) play a crucial role in controlling a variety of physiological and pathological immune responses. In this review we have focused on the physiological alteration of Treg cell infiltration into the endometrium during the reproductive processes of women. We discuss how a disturbance in Treg cell expansion is involved in generating such pathological processes as miscarriage and ectopic pregnancy development. We hypothesize about the role Treg cells might play in the survival of endometriosis foci in ectopic localization and in the evasion of such lesions from host immune surveillance. |
Primary author: | Basta, Pawel Koper, Krzysztof Kazmierczak, Wojciech Wisniewski, Michal Makarewicz, Adrianna Dutsch-Wicherek, Magdalena Kojs, Zbigniew Popiela, Tadeusz J. Slusarz, Robert Dubiel, Mariusz Wicherek, Lukasz |
URI: | http://hdl.handle.net/10201/75529 |
Document type: | info:eu-repo/semantics/article |
Number of pages / Extensions: | 17 |
Rights: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Appears in Collections: | Vol.29, nº10 (2014) |
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Basta-29-1217-1233-2014.pdf | 306,4 kB | Adobe PDF | ![]() View/Open |
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