Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/74910

Title: Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity
Issue Date: 2014
Publisher: F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
Citation: Histology and Histopathology, vol. 29, nº 9, (2014)
ISSN: 1699-5848
0213-3911
Related subjects: CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología
Keywords: Embryo implantation
Endometrium
Implantation failure
Immune responses
Abstract: Human cycling endometrium displays a series of periodic transitions unique to this mucosal tissue, which includes rapid proliferation, secretory transformation, physiological angiogenesis, interstitial edema, and menstrual shedding. Among these properties of the endometrium are the inflammatory changes that occur dynamically across the menstrual cycle. Immunocompetent cell composition and inflammatory gene expression pattern in the human endometrium drastically fluctuate from the proliferative phase to the secretory phase, particularly at the time of ovulation. These local immune responses are fine-tuned by the direct or indirect action of two representative ovarian steroids, estradiol and progesterone, and are essential for successful blastocyst implantation. Meanwhile, studies have been accumulating the evidence that such physiological endometrial inflammatory status is altered in the presence of certain gynecologic pathologies. Given that blastocysts are semi-allografts for maternal tissue, even subtle alterations in endometrial immunity potentially have a negative impact on implantation process. In this article, we aimed to review and discuss the physiological and pathological mucosal inflammatory conditions that can affect endometrial receptivity.
Primary author: Kitaya, Kotaro Kitaya
Yasuo, Tadahiro
Tada, Yoshihiro
Hayashi, Terumi
Iwaki, Yuri
Karita, Masako
Funabiki, Miyako
Taguchi, Sagiri
Spillers, Dustin
Nakamura, Yoshitaka
Yamada, Hisao
URI: http://hdl.handle.net/10201/74910
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 15
Rights: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
Appears in Collections:Vol.29, nº 9 (2014)

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