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Título: | Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity |
Fecha de publicación: | 2014 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol. 29, nº 9, (2014) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología |
Palabras clave: | Embryo implantation Endometrium Implantation failure Immune responses |
Resumen: | Human cycling endometrium displays a series of periodic transitions unique to this mucosal tissue, which includes rapid proliferation, secretory transformation, physiological angiogenesis, interstitial edema, and menstrual shedding. Among these properties of the endometrium are the inflammatory changes that occur dynamically across the menstrual cycle. Immunocompetent cell composition and inflammatory gene expression pattern in the human endometrium drastically fluctuate from the proliferative phase to the secretory phase, particularly at the time of ovulation. These local immune responses are fine-tuned by the direct or indirect action of two representative ovarian steroids, estradiol and progesterone, and are essential for successful blastocyst implantation. Meanwhile, studies have been accumulating the evidence that such physiological endometrial inflammatory status is altered in the presence of certain gynecologic pathologies. Given that blastocysts are semi-allografts for maternal tissue, even subtle alterations in endometrial immunity potentially have a negative impact on implantation process. In this article, we aimed to review and discuss the physiological and pathological mucosal inflammatory conditions that can affect endometrial receptivity. |
Autor/es principal/es: | Kitaya, Kotaro Kitaya Yasuo, Tadahiro Tada, Yoshihiro Hayashi, Terumi Iwaki, Yuri Karita, Masako Funabiki, Miyako Taguchi, Sagiri Spillers, Dustin Nakamura, Yoshitaka Yamada, Hisao |
URI: | http://hdl.handle.net/10201/74910 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 15 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.29, nº 9 (2014) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Kitaya-29-1113-1127-2014.pdf | 7,07 MB | Adobe PDF | Visualizar/Abrir |
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